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The side effects are similar for all three PDE-5 inhibitors and include headache, flushing, nasal congestion, and dyspepsia. Which is better Viagra, Cialis or Levitra. Cialis clearly works for 36 hours or more, making it an ideal choice for men who are very sexually active.

The reactants are then released and the enzyme can work on another molecule of the substrate. In this case, the enzyme is PDE and the substrate is cGMP. The PDE breaks down the cGMP.

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