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Patients who reach their 18th birthday while receiving peginterferon alfa-2b plus ribavirin should remain on the pediatric dosing regimen. -Patients with previous nonresponse, previous pegylated interferon treatment, significant bridging fibrosis or cirrhosis, andor genotype 1 infection are less likely to benefit from retreatment after a failing course of therapy. 5 years or older: In combination with peginterferon alfa-2a: 23 to 33 kg: 200 mg orally twice a day. 34 to 46 kg: 200 mg orally in the morning and 400 mg in the evening.

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