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2008;135(4):762-770. Wolf A, Zalpour C, Theilmeier G, et al. Dietary L-arginine supplementation normalizes platelet aggregation in hypercholesterolemic humans. J Am Coll Cardiol.

Why it's important to check for interactions. Drug interactions are important to check for because they can: Affect how your medication works by changing levels of the drug in your blood Put you at risk for side effects and toxicity Worsen a medical condition you may already have. Checking for a drug interaction before it occurs can drastically lower your chance of a problem. Usually, your doctor and pharmacist will have already done this with your prescription medications, but it‚s a good idea to double check and learn about these medications yourself. If you use any over-the-counter (OTC) medicine, including vitamins, herbal or food supplements, be sure to review these products for interactions with your prescription medications, too.

McMahon CG, Smali R, Johnson H "Efficacy, safety and patient acceptance of sildenafil citrate as treatment for erectile dysfunction. " J Urol 164 (2000): 1192-6. Brindis RG, Kloner RA "Sildenafil in patients with cardiovascular disease.]