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5862 In human microvascular endothelial cells, nitric oxide regulated tissue factor, reducing endotoxin and cytokine-induced expression. Increased concentrations of L-arginine may improve vascular disease by maintaining nitric oxide levels. 44454664. In a randomized clinical trial designed to evaluate the effect of L-arginine 9 gday supplementation for 6 months following an acute ST-segment elevation myocardial infarction, no significant change in vascular stiffness or left ejection fraction was shown. However, 8.

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