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Diminished global arginine bioavailability and increased arginine catabolism as metabolic profile of increased cardiovascular risk. J Am Coll Cardiol. 2009;53(22):2061-2067. Bath PM, Willmot M, Leonardi-Bee J, Bath FJ. Nitric oxide donors (nitrates), Salsman, or nitric oxide synthase inhibitors for acute stroke.

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Also, when the arteries undergo what is called 'endothelial dysfunction,' and are incapable of dilating sufficiently, adding additional l-arginine can correct the condition by inducing nitric oxide up-regulation, subsequently increasing blood flow, which can lead to resolution of cardiovascular dysfunction, including erectile dysfunction. We have indexed no less than six clinical studies on l-arginineeither alone or in combination with another nutraceutical, indicating it can contribute to a reversal of erectile dysfunction. You can view the studies here.]