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Diltiazem can inhibit (block) the CYP450 3A4 enzymes needed for the breakdown (metabolism) of simvastatin. High blood levels of simvastatin can lead to serious liver and muscle side effects. Excretion: Some nonsteroidal antiinflammatory drugs (NSAIDs), like indomethacin, may lower kidney function and affect the excretion of lithium, a drug used for bipolar disorder. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications together.

Adverse Reactions. L-arginine has few reported adverse reactions. Nausea and diarrhea have been reported infrequently. Bitter taste may occur with higher doses. Due to its vasodilatory effects, hypotension may occur. Intravenous (IV) preparations containing L-arginine hydrochloride have a high chloride content that may increase the risk for metabolic acidosis in patients with electrolyte imbalances.

Answers from Contributors (1) 29 Helpful Votes. User-generated content areas are not reviewed by a WebMD physician.]